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Herbs & Supplements

Samento
Scientific Name: Cat's Claw
Other Names: Peruvian Cat's Claw, Saventaro, Una de Gato, Uncaria guianensis, Uncaria tomentosa

References

Aguilar JL, Rojas P, Marcelo A, Plaza A, Bauer R, Reininger E, Klaas CA, Merfort I. Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae). Journal of Ethnopharmacology. 2002;81(2):271-276.

Akesson C, Lindgren H, Pero RW, Leanderson T, Ivars F. An extract of Uncaria tomentosa inhibiting cell division and NF-kappa B activity without inducing cell death. International Immunopharmacology. 2003;3(13-14):1889-1900.

Akesson CH, Pero RW, Ivars F. C-Med 100, a hot water extract of Uncaria tomentosa, prolongs lymphocyte survival in vivo. Phytomedicine. 2003;10(1):23-33.

Allen-Hall L, Cano P, Arnason JT, Rojas R, Lock O, Lafrenie RM. Treatment of THP-1 cells with Uncaria tomentosa extracts differentially regulates the expression if IL-1beta and TNF-alpha. Journal of Ethnopharmacology. 2007;109(2):312-317.

Anon: Cat's claw (una de gato). In: DerMarderosian A, Beutler JA, eds. Facts and Comparisons: The Review of Natural Products. St. Louis, MO, Facts and Comparisons. April 1996.

Aquino R, De Feo V, De Simone F, Pizza C, Cirino G. Plant metabolites. New compounds and anti-inflammatory activity of Uncaria tomentosa. Journal of Natural Products. 1991;54(2):453-459.

Blumenthal M. Una de gato (cat's claw): rainforest herb gets scientific and industry attention. Whole Foods. 1995:65.

Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7(4):273-282.

Chen CX, Jin RM, Li YK, Zhong J, Yue L, Chen SC, Zhou JY. Inhibitory effect of rhynchophylline on platelet aggregation and thrombosis. Zhongguo Yao Li Xue Bao. 1992;13(2):126-130.

Cheng AC, Jian CB, Huang YT, Lai CS, Hsu PC, Pan MH. Induction of apoptosis by Uncaria tomentosa through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia cells. Food Chemistry and Toxicology. 2007;45(11):2206-2218.

Eberlin S, dos Santos LM, Queiroz ML. Uncaria tomentosa extract increases the number of myeloid progenitor cells in the bone marrow of mice infected with Listeria monocytogenes. International Immunopharmacology. 2005;5(7-8):1235-1246.

Frackowiak T, Baczek T, Roman K, et al. Binding of an oxindole alkaloid from Uncaria tomentosa to amyloid protein (Abeta1-40). Zeitschrift fuer Naturforschung. Section C. Biosciences. 2006;61(11-12):821-826.

Garcia Prado E, Garcia Gimenez MD, De la Puerta Vazquez R, Espartero Sanchez JL, Saenz Rodriguez MT. Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines. Phytomedicine. 2007;14(4):280-284.

Gonzales GF, Valerio LG Jr. Medicinal plants from Peru: a review of plants as potential agents against cancer. Anticancer Agents and Medicinal Chemistry. 2006;6(5):429-444.

Groom SN, Johns T, Oldfield PR. The potency of immunomodulatory herbs may be primarily dependent upon macrophage activation. Journal of Medicinal Food. 2007;10(1):73-79.

Hardin SR. Cat's claw: an Amazonian vine decreases inflammation in osteoarthritis. Complementary Therapy in Clinical Practice. 2007;13(1):25-28.

Horie S, Yano S, Aimi N, Sakai S, Watanabe K. Effects of hirsutine, an antihypertensive indole alkaloid from Uncaria rhynchophylla, on intracellular calcium in rat thoracic aorta. Life Sciences. 1992;50(7):491-498.

Hughes K, Worth T. NewCrop FactSHEET. Cat's claw. Purdue University Center for New Crops and Plant Products. Last updated: December 22, 1999. Available at: http://www.hort.purdue.edu/newcrop/CropFactSheets/c atsclaw.html#Culture. Accessed October 14, 2003.

Jellin JM, Gregory P, Batz F, Hitchens K, et al, eds. Pharmacist's Letter/Prescriber's Letter. Natural Medicines Comprehensive Database, 3rd Edition. Stockton CA: Therapeutic Research Facility, 2000.

Jurgensen S, Dalbo S, Angers P, Santos AR, Ribeiro-do-Valle RM. Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa. Pharmacology, Biochemistry and Behavior. 2005;81(3):466-477.

Kemper KJ. Cat's claw (Uncaria tomentosa). The Longwood Herbal Task Force. Revised July 29, 1999. Available at: http://www.mcp.edu/herbal/.pdf Accessed: September 23, 2003.

Keplinger K, Laus G, Wurm M, Dierich MP, Teppner H. Uncaria tomentosa (Willd.) DC.-- ethnomedicinal use and new pharmacological, toxicological and botanical results. Journal of Ethnopharmacology. 1999;64(1):23-34.

Lemaire I, Assinewe V, Cano P, Awang DV, Arnason JT. Stimulation of interleukin-1 and -6 production in alveolar macrophages by the neotropical liana, Uncaria tomentosa (una de gato). Journal of Ethnopharmacology. 1999;64(2):109-115.

Mammone T, Akesson C, Gan D, Giampapa V, Pero RW. A water soluble extract from Uncaria tomentosa (Cat's Claw) is a potent enhancer of DNA repair in primary organ cultures of human skin. Phytotherapy Research. 2006;20(3):178-183.

Miller MJ, Ahmed S, Bobrowski P, Haqqi TM. The chrondoprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1beta. BMC Complementary and Alternative Medicine. 2006;6:13.

Miller MJ, Mehta K, Kunte S, et al. Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: a randomized controlled trial [ISRCTN38432711]. Journal of Inflammation (London). 2005;2:11.

Moreno SR, Silva AL, Dire G, et al. Effect of oral ingestion of an extract of the herb Uncaria tomentosa on the biodistribution of sodium pertechnetate in rats. Brazilian Journal of Medical Biology Research. 2007;40(1):77-80.

Mur E, Hartig F, Eibl G, Schirmer M. Randomized double blind trial of an extract from the pentacyclic alkaloid-chemotype of uncaria [sic] tomentosa for the treatment of rheumatoid arthritis. Journal of Rheumatology. 2002;29:678-681.

Pilarski R, Zielinski H, Ciesiolka D, Gulewicz K. Antioxidant activity of ethanolic and aqueous extracts of Uncaria tomentosa (Willd.) DC. Journal of Ethnopharmacology. 2006;104(1-2):18-23.

Piscoya J, Rodriguez Z, Bustamante SA, Okuhama NN, Miller MJ, Sandoval M. Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis. Inflammation Research. 2001;50(9):442-448.

Reinhard, KH. Uncaria tomentosa (Willd.) D.C.: cat's claw, una de gato, or saventaro. The Journal of Alternative and Complementary Medicine. 1999;5(2):143-151.

Riva L, Coradini D, Di Fronzo G, et al. The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line. Anticancer Research. 2001;21(4A):2457-2461.

Rizzi R, Re F, Bianchi A, et al. Mutagenic and antimutagenic activities of Uncaria tomentosa and its extracts. Journal of Ethnopharmacology. 1993;38(1):63-77.

Sandoval M, Charbonnet RM, Okuhama NN, et al. Cat's claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection. Free Radicals in Biology and Medicine. 2000;29(1):71-78.

Sandoval M, Okuhama NN, Zhang XJ, et al. Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content. Phytomedicine. 2002;9(4):325-337.

Santa Maria A, Lopez A, et al. Evaluation of the toxicity of Uncaria tomentosa by bioassays in vitro. Journal of Ethnopharmacology. 1997;57(3):183-187.

Sheng Y, Bryngelsson C, Pero RW. Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa. Journal of Ethnopharmacology. 2000;69(2):115-126.

Sheng Y, Li L, Holmgren K, Pero RW. DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study. Phytomedicine. 2001;8(4):275-282.

Sheng Y, Pero RW, Amiri A, Bryngelsson C. Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria tomentosa. Anticancer Research. 1998;18(5A):3363-3368.

Sheng Y, Pero RW, Wagner H. Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa. Phytomedicine. 2000;7(2):137-143.

Shi JS, Kenneth HG. Effect of rhynchophylline on apoptosis induced by dopamine in NT2 cells. Acta Pharmacologica Sineca. 2002;23(5):445-449.

Shi JS, Liu GX, Wu Q, Huang YP, Zhang XD. Effects of rhynchophylline and isorhynchophylline on blood pressure and blood flow of organs in anesthetized dogs. [Article in Chinese] Zhongguo Yao Li Xue Bao. 1992;13(1):35-38.

Shi JS, Yu JX, Chen XP, Xu RX. Pharmacological actions of Uncaria alkaloids, rhynchophylline and isorhynchophylline. Acta Pharmacologica Sineca. 2003;24(2):97-101.

Steinberg PN. Cat's Claw: an herb from the Peruvian Amazon. [Article in Spanish] Sidahora. 1995;35-36.

Styczynski J, Wysocki M. Alternative medicine remedies might stimulate viability of leukemic cells. Pediatric Blood Cancers. 2006;46(1):94-98.

Taylor L. Herbal Secrets of the Rainforest, 2nd edition. Roseville, California. Prima Publishing, Inc. 2002.

Wang XL, Zhang LM, Hua Z. Blocking effect of rhynchophylline on calcium channels in isolated rat ventricular myocytes. Zhongguo Yao Li Xue Bao. 1994;15(2):115-118.

Wang XL, Zhang LM, Hua Z. Effect of rhyncophylline on potassium channels in isolated rat or guinea pig ventricular myocytes. Yao Xue Xue Bao. 1994;29(1):9-14.

Williams JE. Review of antiviral and immunomodulating properties of plants of the Peruvian rainforest with a particular emphasis on Una de Gato and Sangre de Grado. Alternative Medicine Review. 2001;6(6):567-579.

Winkler C, Wirleitner B, Schroecksnadel K, Schennach H, Mur E, Fuchs D. In vitro effects of two extracts and two pure alkaloid preparations of Uncaria tomentosa on peripheral blood mononuclear cells. Planta Medica. 2004;70(3):205-210.

Yano S, Horiuchi H, Horie S, Aimi N, Sakai S, Watanabe K. Ca2+ channel blocking effects of hirsutine, an indole alkaloid from Uncaria genus, in the isolated rat aorta. Planta Medica. 1991;57(5):403-405.

Zhang WB, Chen CX, Sim SM, Kwan CY. In vitro vasodilator mechanisms of the indole alkaloids rhynchophylline and isorhynchophylline, isolated from the hook of Uncaria rhynchophylla (Miquel). Naunyn Schmiedebergs Arch Pharmacol. 2004;369(2):232-238.

Last Revised October 5, 2007

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Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.

In general, herbal products are not subject to review or approval by the U.S. Food and Drug Administration (FDA). They are not required to be standardized, meaning that the amounts of active ingredients or contaminants they contain may vary between brands or between different batches of the same brand. Not all of the risks, side effects, or interactions associated with the use of herbal products are known because few reliable studies of their use in humans have been done.

This information is provided for your education only. Please share this information with your healthcare provider and be sure that you talk to your doctor and pharmacist about all the prescription and non-prescription medicines you take before you begin to use any herbal product.

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